Accelerated response of hepatic DNA synthesis to partial hepatectomy in rats pretreated with growth hormone or surgical stress.
نویسندگان
چکیده
The rise in hepatic DNA synthesis in response to partial hepatectomy was accelerated in rats subjected to surgery 4.5 to 8 hr or 3 days before hepatectomy. Bovine growth hor mone, in doses from 0.03 to 2.0 mg, also accelerated the response to hepatectomy, but cortisone, hydrocortisone, and adrenocorticotropic hormone were ineffective. Neither surgery nor growth hormone stimulated DNA synthesis significantly in the livers of nonhepatectomized rats.
منابع مشابه
Accelerated Response of Hepatic DNA Synthesis to Partial Hepatectomy in Rats Pretreated with Growth Hormone or Surgical Stress1
The rise in hepatic DNA synthesis in response to partial hepatectomy was accelerated in rats subjected to surgery 4.5 to 8 hr or 3 days before hepatectomy. Bovine growth hor mone, in doses from 0.03 to 2.0 mg, also accelerated the response to hepatectomy, but cortisone, hydrocortisone, and adrenocorticotropic hormone were ineffective. Neither surgery nor growth hormone stimulated DNA synthesis ...
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متن کاملGlyoxalase activity in sham- and partially hepatectomized rats.
In male rats, hepatic glyoxalase activity and reduced glutathione, the cofactor for this enzyme system, approximately double 12 hr after partial (2/3) or sham hepatectomy, in which the liver lobes were handled during the sham operation. These changes precede by 10 to 12 hr the anticipated DNA synthesis after partial hepatectomy and by about 24 hr the smaller, but prolonged, DNA synthesis that o...
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ورودعنوان ژورنال:
- Cancer research
دوره 30 9 شماره
صفحات -
تاریخ انتشار 1970